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Free Light Chains, Quantitative, Urine
Ordering Recommendation
Aid in the monitoring of patients with urinary monoclonal proteins (Bence Jones protein).
New York DOH Approval Status
Specimen Required
24-hour urine. Refrigerate during collection. Also acceptable: Random urine and urine supernatant.
Transfer 1 mL aliquot from a well-mixed 24-hour collection to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Record total volume and collection time interval on transport tube and test request form.
Ambient: Unacceptable; Refrigerated: 3 weeks; Frozen: 6 months
Methodology
Quantitative Immunoturbidimetry
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Free Urinary Kappa Light Chains | 0.00 - 32.90 mg/L | |
| Free Urinary Kappa Excretion/Day | Refer to Report | |
| Free Urinary Lambda Light Chain | 0.00 - 3.79 mg/L | |
| Free Urinary Lambda Excretion/Day | Refer to Report | |
| Total Protein | Less than 150 mg/d |
Interpretive Data
Results of urine free light chain testing can be used to monitor disease progression or response to therapy in patients for whom urine electrophoresis is unable to provide reliable Bence Jones Protein quantification. The results of urine kappa and lambda free light chains must be interpreted in conjunction with urine immunofixation. The free light chain quantitative values may be misleading in specimens with high levels of urinary polyclonal free light chains, and absent Bence Jones protein by immunofixation; therefore correlation with urine immunofixation is required to identify inconsistent results.
Total Urinary protein is determined turbidimetrically by adding the albumin and kappa and/or lambda light chains. This value may not agree with the total protein as determined by chemical methods, which characteristically underestimates urinary light chains.
Undetected antigen excess is a rare event but cannot be excluded. Free light chain results should always be interpreted in conjunction with other clinical and laboratory findings.
FDA
Note
Hotline History
CPT Codes
84156; 83521 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050565 | Total Protein | 2889-4 |
| 0050683 | Free Urinary Kappa Light Chains | 38176-4 |
| 0050684 | Free Urinary Kappa Excretion/Day | 38177-2 |
| 0050685 | Free Urinary Lambda Light Chain | 38178-0 |
| 0050686 | Free Urinary Lambda Excretion/Day | 38169-9 |
| 0097110 | Total Volume | 19153-6 |
| 0097111 | Hours Collected | 30211-7 |
Aliases
- Free Urine Kappa/Lambda
- Urine Kappa/Lambda FLC
